Magic sponges

时间:2019-03-06 02:15:02166网络整理admin

TINY sponges may be the key to antisense therapy. Small sections of DNA known as antisense oligonucleotides can be used to tackle a wide range of disorders, because they bind to RNA and block the production of specific proteins. But the challenge is getting oligonucleotides into cells—they can be degraded in the bloodstream, for example. So Patrick Couvreur and his colleagues at the University of Paris are soaking them up into protective “nanosponges” made of a sugary gel called alginate. When injected into mice,